Science

Our Science | Vitality Supplements — NAD+ Research & Quality Testing
Vitality Supplements · Evidence-Informed

Formulated on published science.

Every product in the Vitality range begins with the research. This page explains what we know, how we formulate, and how we verify every batch before it reaches you.

Food supplements — not medicines. This page contains compositional and process information only.
Background Science

What is NAD+?

NAD+ is a coenzyme present in every living cell. It participates in hundreds of metabolic processes and is the subject of a substantial and growing body of peer-reviewed scientific research.

NAD+ (Nicotinamide Adenine Dinucleotide) is found across all forms of life. It exists in two forms — NAD+ (oxidised) and NADH (reduced) — and cycles between them as part of normal cellular metabolism.

Published research has documented that NAD+ levels decline with age in human tissue. This decline has been measured across multiple peer-reviewed studies and is one of the most reproduced findings in the longevity research field. The mechanisms by which NAD+ participates in cellular processes — including its role as a substrate for certain enzyme classes — are well established in the scientific literature.

Vitality Supplements formulates its products based on published peer-reviewed human research. We do not make claims about what our products do to the human body beyond what is permitted under UK food supplement regulations. The compositional information on this page describes the ingredients and what the published science says about them as compounds — not what our products are intended to do.

1906
Year NAD was first identified by Harden and Young. Over a century of scientific investigation.
500+
Enzymatic reactions in which NAD+ participates as a cofactor, documented in published biochemical literature.
30+
Peer-reviewed human studies reviewed in the development of our formulations. Dose selection based on published protocols.
Ingredient Information

The ingredients

Compositional descriptions only. These are not health claims. All products are food supplements.

500–
750mg per serving
NMN
Nicotinamide Mononucleotide · β-NMN
Raise · NAD+ Precursor

NMN is a naturally occurring compound found in trace amounts in foods including edamame, broccoli, cucumber and avocado. Chemically, it is a nucleotide derived from ribose and nicotinamide. It is a biosynthetic precursor to NAD+ in the salvage pathway of NAD+ synthesis.

As a food supplement ingredient, NMN is permitted for sale in the United Kingdom. Vitality provides β-NMN at doses aligned with published peer-reviewed human research protocols, at greater than 99% purity verified by independent ISO/IEC 17025-accredited laboratory testing on every production batch.

β-NMN form >99% purity Batch tested UK permitted ingredient
Ingredient role descriptor — food supplement. Not a health claim.
500mg per serving
NMNH
Dihydronicotinamide Mononucleotide
Raise · Reduced NAD+ Precursor

NMNH is the reduced form of NMN — a structurally distinct compound in which the nicotinamide ring is in its reduced state. It is a subject of active scientific investigation and is distinct from NMN in its chemical structure and properties.

Vitality provides NMNH at 500mg per serving at greater than 99% purity, independently verified on every production batch by an ISO/IEC 17025-accredited laboratory. NMNH is a newer ingredient and the published human research base is less extensive than that for NMN.

Reduced form of NMN >99% purity Batch tested Active research area
Ingredient role descriptor — food supplement. Not a health claim.
750mg per serving
TMG
Trimethylglycine · Betaine Anhydrous
Support · Methyl Donor

TMG (Trimethylglycine), also known as betaine, is a naturally occurring compound derived from choline. It is found in beetroot, spinach and quinoa. It functions as a methyl donor in the body's one-carbon metabolism pathway.

The inclusion of TMG alongside NMN is discussed in longevity research literature in the context of methylation balance. It is included in NMN Complete at 750mg per serving.

Betaine anhydrous Methyl donor 750mg dose
Ingredient role descriptor — food supplement. Not a health claim.
50mg per serving
Pterostilbene
Stilbenoid Polyphenol · Blueberry-derived
Activate · Sirtuin-Pathway Polyphenol

Pterostilbene is a stilbenoid polyphenol found naturally in blueberries and grapes. It is structurally related to resveratrol but differs in that it has two methoxy groups rather than two hydroxyl groups — a modification associated with approximately 4x higher oral bioavailability compared to resveratrol in published pharmacokinetic studies.

Pterostilbene is included in NMN Complete at 50mg per serving as the sirtuin-pathway polyphenol in the formula.

~4x bioavailability vs resveratrol 50mg dose Blueberry-derived
Ingredient role descriptor — food supplement. Not a health claim.
50mg per serving
Apigenin
Natural Flavonoid · Chamomile-derived
Protect · CD38 Inhibitor

Apigenin is a flavonoid found in chamomile, parsley and celery. It has been studied in published scientific literature as an inhibitor of CD38, an NAD+-consuming enzyme. CD38 expression is documented to increase with age in published research.

Apigenin is included in NMN Complete at 50mg per serving. It is the CD38 inhibitor component of the NMN Complete formula, included alongside the NAD+ precursor NMN.

CD38 inhibitor 50mg dose Chamomile-derived
Ingredient role descriptor — food supplement. Not a health claim.
600mg per serving
Trans-Resveratrol
98% Trans-Isomer Purity · Polygonum-derived
Activate · Polyphenol

Trans-Resveratrol is a stilbenoid polyphenol produced by plants in response to stress. It is found in red grape skin, Japanese knotweed and peanuts. The trans-isomer is the biologically active form — Vitality provides Trans-Resveratrol at 98% trans-isomer purity at 600mg per serving.

It is one of the most extensively studied polyphenols in the published scientific literature and is paired with NMN in the NMN + Trans-Resveratrol 1100mg formula.

98% trans-isomer 600mg dose Polygonum cuspidatum
Ingredient role descriptor — food supplement. Not a health claim.
Quality Assurance

Independent testing. Every batch.

Every production batch is tested by an independent ISO/IEC 17025-accredited laboratory before release. This is not selective — every batch, without exception.

01
Ingredient Arrival
Every raw ingredient is tested for identity on arrival at the manufacturing facility before it enters production. Substandard or non-conforming materials are rejected.
Identity testing
02
Production
Products are manufactured in a GMP-certified UK facility under documented, controlled conditions. Batch records are maintained throughout.
GMP certified
03
Independent Laboratory
The finished batch is sent to an independent ISO/IEC 17025-accredited laboratory. Testing covers potency, identity, heavy metals, microbial contamination and allergens.
ISO/IEC 17025
04
Release or Reject
If the batch passes all specifications, it is released. If it fails any single specification, it does not ship. The Certificate of Analysis is available on request for every released batch.
CoA available
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Potency & Identity
Active ingredient confirmed present at the stated dose. Identity verified against reference standards.
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Heavy Metals
Lead, cadmium, arsenic and mercury tested on every batch against established safety limits.
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Microbial Safety
Total aerobic plate count, yeast, mould, E. coli and Salmonella tested on every production batch.
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Allergen Screening
All 14 major EU/UK regulated allergens screened on every batch before release.
UK Manufacturing

Made here.
Tested here.

Every Vitality product is formulated and manufactured in the United Kingdom. Not imported and relabelled. Not produced overseas to an unknown standard.

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UK Manufactured
Every product is produced in a GMP-certified facility in the United Kingdom. GMP (Good Manufacturing Practice) is the same standard applied to pharmaceutical manufacturing.
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Batch Records
Full batch documentation is maintained for every production run, including ingredient sourcing, manufacturing conditions, and test results. Every pouch carries its batch number.
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Vegan & Clean
All products use HPMC plant-derived capsules. Free from gluten, dairy, soy, nuts and GMOs. No artificial colours, fillers or proprietary blends.
Regulatory & Compliance Information

All Vitality Supplements products are food supplements regulated under UK food supplement legislation (The Food Supplements (England) Regulations 2003 and devolved equivalents). They are not medicines and are not intended to diagnose, treat, cure or prevent any disease or medical condition.

Health claims on food supplements sold in the UK are governed by retained EU Regulation 1924/2006 (as amended) and enforced by the ASA, CAP and Trading Standards. Claims made by Vitality Supplements are restricted to permitted compositional and process claims. No unauthorised health claims are made.

The ingredient role descriptors used on this page and on product labelling (Raise, Support, Activate, Protect) are compositional descriptors indicating the ingredient's role within the formula — they are not health claims and are not intended to imply any effect on human health or body function.

Do not exceed the recommended serving size. Food supplements are not a substitute for a varied and balanced diet and a healthy lifestyle. Consult a qualified healthcare professional before use if you are pregnant, breastfeeding, taking prescription medication, or have a pre-existing medical condition. Keep out of reach of children. Store below 25°C in a dry place away from direct sunlight.

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Evidence-informed. UK manufactured. Third-party tested every batch.

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