PEA Dosage: The 300-1200mg Study Range and What Your Label Means
PEA dosage: the range studies use, and the number your label leaves out.
Palmitoylethanolamide doses are quoted online with a confidence the literature does not support. Here is the actual range, the protocol that recurs, and why grade and dose have to be read together.
Published human PEA trials commonly use 300–1200mg per day, and the pattern that recurs most often is 600mg twice daily, over periods from a few weeks to several months in adults. Some protocols run a higher initial intake and then step down to maintenance. Doses in that literature are doses of micronised or ultra-micronised material, so grade and dose belong together.
The range, and why it is a range
PEA's dose literature is wider and less settled than a single confident number would suggest. Trials differ in formulation grade, in endpoint, in population and in duration, and many are modest in size. A quoted "standard dose" collapses all of that into a figure that looks more established than it is.
| Daily amount | Where it appears |
|---|---|
| 300mg/day | Lower end of published protocols; also seen as a maintenance step-down |
| 600mg/day | Common, as a single daily amount |
| 1200mg/day | Common, usually as 600mg twice daily — the most frequently recurring pattern |
| Higher initial, lower maintenance | A design choice in a number of trials, not an established rule |
Why grade belongs in the same sentence as dose
PEA is practically insoluble in water — log P above 5 — so how much of a given weight actually dissolves depends heavily on particle size. Milligrams are milligrams either way: 600mg of standard-grade material is the same weight of compound as 600mg micronised. What differs is dissolution.
The consequence for reading research is direct. Most clinical protocols used micronised or ultra-micronised material, so a dose lifted from that literature is implicitly a dose of that grade. Applying it to a product whose label does not state grade means you are matching one number and ignoring the variable the researchers controlled for. That is the single most common mistake in this category.
Our serving size
Our PEA capsules are 600mg per serving — which maps cleanly onto either the 600mg once-daily or the 600mg twice-daily pattern in the literature, and makes the cost arithmetic straightforward. At one serving a day, a 60-capsule pot is 30 days; at two, it is 15.
Being consistent about our own gaps: our label does not currently state micronisation grade, which is precisely the thing this page tells you to check. Ask us and we will send what the specification says.
Why this page gives no dosing advice
Deliberate, for two reasons that compound each other.
PEA has no authorised health claims in Great Britain or the EU. A recommended dose is always a dose for a purpose — so recommending one would be an unauthorised claim by implication, and in most phrasings a medicinal claim, which a food supplement may not make at all under any circumstances.
And separately: a company selling PEA is not a suitable source of personalised advice about your medication, history or circumstances. What we can do accurately is report what the research used, state our own serving size, and be clear about what our label omits. For anything beyond that, ask a pharmacist or your GP.