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A Complete Science-Based Guide
Five pillars of longevity biology — explained accurately, with the published research cited and the limitations acknowledged. Written by a UK manufacturer that earns trust by testing every batch.
Last updated · Written by Vitality Supplements Editorial Team · 15 min read · 500+ papers reviewed
The biology of ageing has been one of the most active areas of peer-reviewed research over the past two decades. The findings are genuinely significant — documented changes in NAD+ metabolism, sirtuin enzyme activity, mitochondrial function and cellular stress responses that occur with age have been reproduced across independent research groups worldwide.
Yet most public coverage falls into one of two categories: breathless claims that overstate what is known, or reflexive scepticism that ignores what the published research actually shows. Neither serves the person trying to make informed decisions.
The Vitality Longevity Protocol is our attempt to do it properly. Five pillars of longevity science, explained accurately, with the published research cited, the limitations acknowledged, and practical implications drawn honestly.
"The science of ageing has never been more advanced.
Understanding it has never been more important."
Each pillar is a deep-dive into one area of longevity biology — the science, the published research and what it means in practice.
The coenzyme at the centre of longevity biology. What NAD+ is, why published research documents its decline with age, the PARP and CD38 consumption problem, and how precursors like NMN and NMNH relate to it.
The seven NAD+-dependent enzymes most studied in longevity biology. What SIRT1–SIRT7 do, how they require NAD+ to function, and why resveratrol and pterostilbene are studied in this context.
Mitochondria produce the cell's energy currency — and their function declines with age. What published research documents about mitochondrial ageing, biogenesis, mitophagy and the compounds studied in this context.
Chronic low-grade inflammation — "inflammaging" — is one of the most consistently documented features of biological ageing. Senescent cells, oxidative stress, and the compounds studied in cellular stress biology.
Where the science meets practical application. How the ingredients in the Vitality range relate to the four longevity pillars. What doses published research has used. How to build and evaluate a quality longevity supplement protocol. What to look for. What to avoid. Quality criteria explained in full.
Arthur Harden and William John Young identify NAD as a cofactor in yeast fermentation. The molecule that would become central to longevity biology is first described — over a century of research begins.
PARP enzymes are identified. Their role in DNA repair — and their substantial consumption of NAD+ — becomes a key area of ageing biology research.
Landmark research links sirtuins to lifespan extension in model organisms. The connection between NAD+-dependent sirtuins and longevity biology accelerates research interest globally.
Published research documents resveratrol's relationship to SIRT1 activation. The era of longevity polyphenol research begins. NMN's connection to this pathway begins to be understood.
Peer-reviewed research confirms NAD+ levels decline with age in human tissue. A finding reproduced across independent research groups in liver, skeletal muscle, heart and brain.
NMN human research accelerates significantly. By 2023, a systematic review of 10 randomised controlled trials with 437 participants confirms consistent NAD+ elevation with strong safety profile across all studies. See the NMN dosage guide →
All five pillars, the research timeline, the supplement protocol and the buying guide — formatted as a comprehensive reference document you can save, share and return to.
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The compounds covered in this protocol are available as independently tested food supplements. Every product is UK manufactured and tested by an ISO/IEC 17025-accredited laboratory on every production batch. CoA available on request.
Four-ingredient formula. NMN as NAD+ precursor, TMG as methyl donor, pterostilbene as sirtuin-pathway polyphenol, apigenin as CD38-pathway botanical. The most comprehensive formula in the Vitality range.
The classic NAD+ and sirtuin-pathway combination. 500mg NMN as NAD+ precursor combined with 600mg Trans-Resveratrol at 98% trans-isomer purity — the form studied in published sirtuin research.
Dihydronicotinamide Mononucleotide — the reduced form of NMN. A newer NAD+ precursor ingredient with active ongoing research. Greater than 99% purity, independently tested on every batch.
Standardised mushroom extract with one of the most extensive published research bases of any supplement ingredient in cellular biology research contexts. Research origin 1989. 1000mg per serving.
