Email: info@vitality-supplements.co.uk
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Vitality Supplements
12 Deer Park Road
SW19 3TL
London
United Kingdom
Metabolic Series
Metabolic Series
550mg · Full dose
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Dihydroberberine
550mg Complex
Berberine Complex · Metabolic Support · 60 Vegan Capsules · 30 Servings
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Third-party tested — every batch
CoA available on request — email with your batch number
CoA available on request — email with your batch number
5×
Bioavailability
Up to 5× greater intestinal absorption than standard berberine HCl.
550mg
Per serving
200mg DHB + 350mg Organic Ceylon Cinnamon. Full-dose, transparent labelling.
100%
Batches tested
Third-party verified. Every batch, ISO-accredited independent laboratory.
🇬🇧
UK Made
Manufactured and quality-checked in the United Kingdom.
The formula
Two ingredients.
One purpose.
Exact doses on the label. No blends. No fillers. Every ingredient chosen for a specific metabolic role.
200mg
Dihydroberberine
DHB · CAS 522-97-4 · Next-gen berberine
The reduced form of berberine — absorbed upstream in the small intestine at a far higher rate than standard berberine hydrochloride. Once inside cells, DHB is oxidised back to berberine where it is studied for activity on the AMPK pathway — the body's metabolic energy sensor. Same research basis. Fraction of the dose. Near-zero GI discomfort.
- Up to 5× greater absorption than berberine HCl
- Studied for AMPK pathway activity — the cellular energy regulator
- Supports healthy glucose metabolism
- Converts back to berberine in tissues for sustained effect
- Dramatically reduced GI side effects vs standard berberine
Supplement Facts
Serving Size: 2 Capsules | Servings Per Container: 30
| Ingredient | Per Serving | % DV |
|---|---|---|
| Dihydroberberine (DHB) | 200 mg | ** |
| Organic Ceylon Cinnamon Extract Cinnamomum verum | 350 mg | ** |
| Vegetable Cellulose (Capsule) | — | — |
** Daily Value (DV) not established.
Other ingredients: HPMC (Vegan Capsule Shell), Magnesium Stearate (Vegetable Source).
Free from: Gluten, Dairy, Soy, Artificial Colours and Preservatives. Vegan.
Other ingredients: HPMC (Vegan Capsule Shell), Magnesium Stearate (Vegetable Source).
Free from: Gluten, Dairy, Soy, Artificial Colours and Preservatives. Vegan.
350mg
Organic Ceylon Cinnamon
Cinnamomum verum · Standardised extract · Organic certified
True cinnamon — not the cassia variety in most supplements. Ceylon contains negligible coumarin, making it genuinely safe for daily use at this dose. Its polyphenols support blood glucose metabolism through pathways complementary to DHB's AMPK activation, creating a compound synergistic effect neither ingredient achieves alone.
- Cinnamomum verum — not cassia (Cinnamomum aromaticum)
- Negligible coumarin — safe for daily long-term supplementation
- Supports healthy post-meal blood glucose balance
- Organic certified, standardised extract for consistent potency
- Synergistic with DHB — complementary, independent mechanisms
Why not cassia?
Cassia cinnamon — used in most supplements — contains high coumarin levels linked to liver toxicity at supplemental doses. Ceylon (Cinnamomum verum) contains negligible coumarin. If your current cinnamon supplement doesn't specify Cinnamomum verum, it's almost certainly cassia.
The synergy
DHB activates AMPK intracellularly. Ceylon cinnamon polyphenols improve insulin receptor sensitivity and glucose transporter activity through separate receptor pathways. The two work on different parts of the same metabolic system — stacking the effect without stacking the mechanisms.
How we compare
DHB vs standard berberine
| What matters | Vitality DHB Complex | Standard berberine HCl |
|---|---|---|
| Intestinal bioavailability | ✓ Up to 5× greater | ~5% (poor) |
| GI tolerance | ✓ Excellent — minimal discomfort | Common: bloating, cramps |
| AMPK pathway activity | ✓ Yes — via DHB → berberine conversion | Yes — at higher doses |
| Effective dose required | ✓ 200mg DHB | 1000–1500mg typical |
| Cinnamon included | ✓ 350mg Organic Ceylon | Rarely included |
| Cinnamon type | ✓ Cinnamomum verum (safe) | Usually cassia (high coumarin) |
| Third-party tested | ✓ Every batch, ISO-accredited | Rarely disclosed |
| UK manufactured | ✓ UK-manufactured | Often overseas |
The science
What is Dihydroberberine?
Dihydroberberine (DHB) is the reduced form of berberine — a compound found in several plants including barberry (Berberis vulgaris), goldenseal, and tree turmeric. It is the direct metabolic product that gut bacteria produce from berberine via reduction. CAS number: 522-97-4.
The bioavailability problem with standard berberine has been well-documented: intestinal absorption is approximately 5%, meaning most of the dose never reaches systemic circulation. DHB bypasses this limitation — absorbed upstream in the small intestine at a far higher rate. Once inside cells, it is oxidised back to berberine, where it activates AMPK (adenosine monophosphate-activated protein kinase), the enzyme that regulates cellular energy balance, glucose uptake, lipid metabolism, and mitochondrial function.
AMPK is sometimes called the metabolic master switch — it is the same pathway activated by exercise and caloric restriction, both of which have well-established associations with metabolic health and longevity. Berberine and its derivatives are the only known oral compounds that activate AMPK with meaningful potency from standard supplemental doses.
Compound class
Isoquinoline alkaloid · Berberine metabolite
Produced by gut bacteria from berberine. Absorbs in small intestine; converts to berberine intracellularly.
Mechanism
AMPK pathway activity
Adenosine monophosphate-activated protein kinase — the cellular energy sensor studied in relation to glucose, lipid, and mitochondrial metabolism. DHB is researched for its role in this pathway.
CAS number
522-97-4
Dihydroberberine. Distinct from berberine HCl (CAS 633-65-8) in reduction state and intestinal transport mechanism.
Research context: The majority of published research on berberine and AMPK activation was conducted using standard berberine HCl. Research on DHB specifically is a newer and smaller body of work, most of it pharmacokinetic — studying absorption and conversion rather than clinical outcomes. We are transparent about this. Dihydroberberine is a metabolic support food supplement, not a pharmaceutical. The absorption advantage is well-characterised; the clinical outcome data for DHB specifically is still developing.
Complete your protocol
Stack with Vitality Supplements
Dihydroberberine works as a standalone metabolic support supplement. Many customers combine it with NAD+ precursors and other longevity compounds for a broader protocol.
Learn more
Go deeper into the science
We've written comprehensive guides on DHB — what it is, how it works, and how it stacks up against standard berberine. No fluff. Just the science.
Complete Guide
What is Dihydroberberine?
The complete guide to DHB — what it is, how it's produced, how it activates AMPK, and why bioavailability matters for metabolic supplements.
Read the guide →
Comparison Guide
Dihydroberberine vs Berberine
A head-to-head breakdown — bioavailability, GI tolerance, effective dose, mechanisms, and who each form is right for.
Read the guide →
Common questions
Frequently asked
Dihydroberberine (DHB) is the reduced form of berberine — produced by gut bacteria from standard berberine. Standard berberine HCl has approximately 5% intestinal absorption; most of the dose never reaches systemic circulation. DHB is absorbed upstream in the small intestine at a far higher rate — up to 5× greater bioavailability in comparative studies. Once inside cells, DHB is oxidised back to berberine where it activates AMPK with the same potency. Same mechanism, fraction of the dose, dramatically better GI tolerance.
Most cinnamon supplements use cassia (Cinnamomum aromaticum or cassia), which contains high levels of coumarin. At supplemental doses taken daily, cassia coumarin can be hepatotoxic. Ceylon (Cinnamomum verum) — true cinnamon — contains negligible coumarin and is safe for daily use. Ceylon's polyphenol profile also has a stronger evidence base for blood glucose support than cassia. If a supplement doesn't specify Cinnamomum verum, assume it's cassia.
Take 2 capsules daily with water, preferably with food — ideally with your largest meal. Taking with food maximises the metabolic effect by blunting post-meal glucose response, and also improves tolerability. Do not exceed 2 capsules in a 24-hour period. For best results, take consistently daily. Most users report noticing meaningful differences in energy consistency and appetite within 3–4 weeks of daily use.
If you are taking prescription medication — particularly diabetes drugs (metformin, insulin, GLP-1 agonists), blood pressure medication, or statins — consult your GP or pharmacist before taking this product. Berberine compounds can interact with these drug classes, particularly those affecting blood glucose or lipid metabolism. This is a precaution, not a contraindication, but GP clearance is important.
Yes. Every batch is tested at an ISO-accredited independent laboratory before release. The Certificate of Analysis (CoA) confirms identity, purity, and potency — including the absence of heavy metals, pesticides, and microbiological contaminants. Email us with your batch number and we'll send the CoA the same day.
Yes. Vitality Supplements Dihydroberberine is encapsulated in HPMC (hydroxypropyl methylcellulose) vegan capsules and is free from gluten, dairy, soy, artificial colours, and preservatives. Suitable for vegans.
We offer a 60-day money-back guarantee, no questions asked. If you're not satisfied for any reason, contact our customer support team within 60 days of purchase for a full refund.
Vitality Supplements Dihydroberberine is manufactured in the United Kingdom in the United Kingdom and is third-party tested for purity and potency on every batch.
60-Day Money-Back Guarantee
Try Dihydroberberine for 60 days. If you're not completely satisfied for any reason, we'll refund you in full — no questions asked. We stand behind every product we make.
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200mg DHB. 350mg Organic Ceylon Cinnamon. Full-dose. Third-party tested every batch. UK manufactured. Vegan. 60-day guarantee.
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Food Supplement Notice: Food supplements must not replace a varied, balanced diet and healthy lifestyle. If pregnant, breastfeeding or on medication, consult a doctor before use. Keep out of reach of children. Store in a cool, dry place. Do not use if seal is broken. Discontinue use and consult a doctor if adverse reactions occur.
Claims Notice: This product is a food supplement. The statements on this page have not been evaluated by the MHRA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Manufactured for: Vitality Supplements · 12 Deer Park Road, London SW19 3TL · vitality-supplements.co.uk
Claims Notice: This product is a food supplement. The statements on this page have not been evaluated by the MHRA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Manufactured for: Vitality Supplements · 12 Deer Park Road, London SW19 3TL · vitality-supplements.co.uk
⚗️
Dihydroberberine 550mg
60 Vegan Capsules · 30 Servings · Third-party tested
£19.99
